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Indicated in non rheumatic AF with one of the following previous stroke or transient ischaemic attack, CCF, age > 75 years, diabetes mellitus or hypertension
Mode of action
- Direct and reversible inhibitor of activated factor Xa
Indications/Dose
- DVT/PE: Edoxaban 60 mg OD following 5 days LMWH, Edoxaban 30 mg OD in those weight < 60 Kg
- Non Rheumatic AF: Edoxaban 60 mg OD, Edoxaban 30 mg OD in those weight < 60 Kg
- DVT/VTE prevention: not licensed.
Interactions
- Ciclosporin, dronedarone, Erythromycin, or Ketoconazole: reduced dose to 30 mg
Cautions
- Other Anticoagulants and antithrombotic drugs or coagulopathy
- High HAS BLED score, Poorly controlled BP, Liver disease
Contraindications
- Renal failure, Active pathological bleeding, Severe hypersensitivity reaction
- Significant risk of major bleeding: GI ulcer, oesophageal varices
- Recent brain, spine, or ophthalmic surgery
- Recent intracranial haemorrhage, malignant neoplasms, vascular aneurysm
Side effects
References