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Antiphospholipid syndrome


Introduction

  • Acquired autoimmune disease also known as Hughes syndrome
  • Possession of antibodies to phospholipids or phospholipid-protein complexes
  • Associated with thrombosis, thrombocytopenia, and recurrent fetal loss
Transient aPL positivity is common during infections and thus documentation of the persistent (at least 12 weeks apart) autoimmune aPL is crucial for diagnostic purposes

Aetiology

  • Acquire antibodies to phospholipids and phospholipid-protein complexes
  • Found on cell membranes and blood vessels
  • Associated with venous/arterial thrombosis and fetal loss
  • There are various suggested mechanisms why APS may cause stroke but all are speculative

The Three Important Antiphospholipid antibodies

  • Lupus anticoagulant (LA)
  • Anticardiolipin antibodies (aCL)
  • Anti-β2-glycoprotein-1 (anti-β2-GP1)

Primary vs Secondary Classification

NameDetails
Primary APSAntiphospholipid antibodies with thrombotic or related obstetric complications but no other underlying cause
Secondary APSAntiphospholipid antibodies with thrombotic or related obstetric complications associated with a causative disease e.g. SLE

Epidemiology

  • Female > Male ratio at least > 2:1
  • Most often white
  • Most are aged 20-40 years old

Clinical Classification

NameDetailsTreatment
Incidental APSAntiphospholipid antibodies but no thrombotic or related obstetric complications (i.e., do not fit criteria for APS). Some may consider low dose aspirin.
APSAntiphospholipid antibodies with arterial or venous thrombosis Usually Aspirin +/- Warfarin.
Obstetric APSantiphospholipid antibodies and a history of pregnancy-related morbidity such as the loss of 3 or more embryos before the 10th week of gestation and/or 1 or more otherwise unexplained fetal deaths beyond the 10th week of gestation, and/or the premature birth of a morphologically normal neonate before the 34th week of gestation because of eclampsia, severe pre-eclampsia, or placental insufficiency but no history of thrombosis and so thrombotic risks hard to assess and determine. Fetal monitoring. Women with recurrent pregnancy loss can receive aspirin +/- prophylactic-dose LMWH and warfarin post partum.
Catastrophic APSAlso called Asherson's syndrome. Antiphospholipid antibodies with multiorgan thrombotic involvement. Often requires treatment with Heparin, intravenous methylprednisolone pulse therapy and plasmapheresis or intravenous immune globulin or rituximab

Clinical

  • Female > Male ratio at least > 2:1
  • Venous Thrombotic episode - Stroke, PE
  • Arterial Thrombotic episode - Stroke/TIA, MI
  • Fetal loss in pregnancy
  • Other symptoms include seizures, myelopathy, headache and memory loss
  • Arthralgia/arthritis, livedo reticularis, petechiae

Investigations

  • FBC (low platelets often seen), U&E, LFTs, ESR, CRP, Cholesterol
  • lupus anticoagulant, Anticardiolipin antibodies, Anti-beta2-glycoprotein I antibodies
  • ANA, double-stranded DNA, and extractable nuclear antigen antibodies
  • Stroke : Brain Imaging CT/MRI/MRA/MRV
  • Thrombophilia screen
  • PE: VQ scan or CTPA
  • Transoesophageal echocardiogram is strongly recommended in APS patients with ischaemic stroke as there is a high yield of valvular abnormalities.
Some people have APS antibodies but no signs or symptoms of the disorder. Having APS antibodies doesn't mean that you have APS. To be diagnosed with APS, you must have APS antibodies and realted cliical evidence of the APS.

Revised classification criteria for the antiphospholipid antibody syndrome

Clinical criteria (one or more)

[1]. Vascular thrombosis: One or more objectively confirmed episodes of arterial, venous or small vessel thrombosis occurring in any tissue or organ
[2]. Pregnancy morbidity:
  • a) one or more unexplained deaths of a morphologically normal fetus at or beyond the 10th week of gestation; or
  • b) one or more premature births of a morphologically normal neonate before the 34th week of gestation because of eclampsia, pre-eclampsia or placental insufficiency; or
  • c) Three or more unexplained consecutive spontaneous abortions before the 10th week of gestation

[3].Laboratory criteria (one or more, present on 2 or more occasions at least 12 weeks apart using recommended procedures)
  • 1. Lupus anticoagulant, detected according to the guidelines of the International Society on Thrombosis and Haemostasis
  • 2. Anticardiolipin antibody of IgG and/or IgM isotype, present in medium or high titer (greater than 40 GPL or MPL, or greater than the 99th percentile), measured by a standardized ELISA
  • 3. Anti-β2-glycoprotein-1 antibody of IgG and/or IgM isotype, present in titer greater than the 99th percentile, measured by a standardized ELISA

Differentials

  • Vasculitis
  • SLE
  • Thrombophilia
  • Atrial myxoma

Management

  • Take a general approach in stroke patients. Look at general vascular risks factors such as obesity, smoking, diabetes, immobilisation, BP, lipids, and if on oestrogen. There can arise a situation in which antibodies are positive in a patient who may have another aetiology. It is for that reason that it is not advised to check in those over the age of 50 unless there is clear clinical indicators e..g. they have SLE. A risk benefit assessment is needed.
  • Anticoagulation: This often requires anticoagulation (warfarin is avoided in pregnancy). The RCP does not recommend testing those over the age of 50. This seems reasonable if there are no other specific red flags. The difficulty is that even with positive APLs there may be an alternative cause of stroke. If for instance that is also an indication to anticoagulant then it is straightforward. If it isn't then it is more difficult and a choice between antiplatelets (Aspirin, Clopidogrel) and anticoagulation (Warfarin, LMWH, DOACs) needs made. For those with definite APS and stroke then initial plan would be warfarin with a a target INR of 2.5. This might be higher for recurrent episodes or those with catastrophic disease. One other concern is that APS is often associated with thrombocytopenia thereby increasing risks of haemorrhage if severe.
  • Immune modulation: Refractory forms of APS may benefit from adding hydroxychloroquine and/or intravenous immunoglobulin to anticoagulation therapy. The role of other immunomodulatory drugs is unclear. These include Riuximab( Binds to CD20 on B cells), Eculizumab (Inhibits the cleavage of C5 to c5a and c5b), Statins (HMG Coa Reductase Inhibitor), Sirolimus

References

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